Principal Investigator

Prof. Sin-Hyeog Im

Professor, Division of Integrative Bioscience and Biotechnology, POSTECH
Group leader, Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS)

​iimsh@postech.ac.kr

Education

• 1983-1987 : B.Sc. Faculty of Life Sciences, Korea University, Seoul, Republic of Korea

• 1987-1989 : M.Sc. Graduate School of Korea University, Seoul, Republic of Korea 

• 1996-2001 : Ph.D. Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

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Professional Record

• 1990-1996 : Senior research scientist, Biotechnology Lab, Research center in Chong KunDang (CKD) Pharm, Seoul, Republic of Korea

• 2001-2003 : Postdoctoral fellow, Harvard Medical School, USA (Prof. Anjana Rao's Lab)                                                                           
                      Subject : Functional Genomic Approaches for regulation of Immunoregulatory Molecules

• 2004-2008 : Assistant Professor, Dept of Life Science, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea

• 2008-2012 : Associates Professor, School of Life Science, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea

• 2012-2013 : Professor, School of Life Science, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea

• 2014-Present : Professor, Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology (POSTECH) and Group leader, Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS), Pohang, Republic of Korea

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Selected Publications

• R Verma et al. Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells. Sci Immunol (2018)

• HK Kwon & GC Kim et al. Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program. Sci Rep. 18;6:19453. (2016) 

• JU Shim, SE Lee & W Hwang et al. Flagellin suppresses experimental asthma by generating regulatory dendritic cells and T cells. J Allergy Clin Immunol. 137(2):426-35. (2016)

• JE Kim, TX Pan & VH Nugyen et al. Salmonella typhimurium suppresses tumor growth via the pro-inflammatory cytokine interleukin-1β. Theranostics. 5(12):1328-1342. (2015)

• JH Ryu & CS Chae et al. Hypoxia-Inducible Factor-2a Is an Essential Catabolic Regulator of Inflammatory Rheumatoid Arthritis. Plos  Biol. 12(6)21001881. (2014)

• JS So, GC Kim & M Song et al. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. J Immunol.  193(6):2772-83. (2014)

• A Jash et al. Nuclear factor of activated T cells 1 (NFAT1)-induced permissive chromatin modification facilitates Nuclear factor-kB (NFkB)-mediated interleukin-9 (IL-9) transactivation. J Biol Chem. 287(19):15445-57. (2012)

• CG Lee et al. Interaction of Ets-1 with HDAC1 represses IL-10 expression in T helper 1 cells. J Immunol. 188(5):2244-253. (2012)

• JS So, HJ Lee & SH Im. Composition for preventing or treating arthritis comprising lactic acid bacteria and collagen as active ingredients. European patent 1945234 (2012)

• HK Kwon et al. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc Natl Acad Sci. 107(5):2159-64. (2010)

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