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Principal Investigator

Prof. Sin-Hyeog Im

Professor, Division of Integrative Bioscience and Biotechnology, POSTECH
โ€‹iimsh@postech.ac.kr

Education

  • 1983-1987 : B.Sc. Faculty of Life Sciences, Korea University, Seoul, Republic of Korea

  • 1987-1989 : M.Sc. Graduate School of Korea University, Seoul, Republic of Korea 

  • 1996-2001 : Ph.D. Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

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Professional Record

  • 1990-1996 : Senior research scientist, Biotechnology Lab, Research center in Chong KunDang (CKD) Pharm, Seoul, Republic of Korea

  • 2001-2003 : Postdoctoral fellow, Harvard Medical School, USA (Prof. Anjana Rao's Lab)                                                                           
                        Subject : Functional Genomic Approaches for regulation of Immunoregulatory Molecules

  • 2004-2008 : Assistant Professor, Dept of Life Science, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea

  • 2008-2012 : Associates Professor, School of Life Science, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea

  • 2012-2013 : Professor, School of Life Science, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea

  • 2014-2019 : Group leader, Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS), Pohang, Republic of Korea

  • 2014-Present : Professor, Department of Life Sciences & Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology (POSTECH) Pohang, Republic of Korea

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Selected Publications

  • CJ Kim et al. The Transcription Factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus. Immunity. (2018)

  • R Verma et al. Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells. Sci Immunol (2018)

  • HK Kwon & GC Kim et al. Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program. Sci Rep. 18;6:19453. (2016) 

  • JU Shim, SE Lee & W Hwang et al. Flagellin suppresses experimental asthma by generating regulatory dendritic cells and T cells. J Allergy Clin Immunol. 137(2):426-35. (2016)

  • JE Kim, TX Pan & VH Nugyen et al. Salmonella typhimurium suppresses tumor growth via the pro-inflammatory cytokine interleukin-1β. Theranostics. 5(12):1328-1342. (2015)

  • JH Ryu & CS Chae et al. Hypoxia-Inducible Factor-2a Is an Essential Catabolic Regulator of Inflammatory Rheumatoid Arthritis. Plos  Biol. 12(6)21001881. (2014)

  • JS So, GC Kim & M Song et al. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. J Immunol.  193(6):2772-83. (2014)

  • A Jash et al. Nuclear factor of activated T cells 1 (NFAT1)-induced permissive chromatin modification facilitates Nuclear factor-kB (NFkB)-mediated interleukin-9 (IL-9) transactivation. J Biol Chem. 287(19):15445-57. (2012)

  • CG Lee et al. Interaction of Ets-1 with HDAC1 represses IL-10 expression in T helper 1 cells. J Immunol. 188(5):2244-253. (2012)

  • JS So, HJ Lee & SH Im. Composition for preventing or treating arthritis comprising lactic acid bacteria and collagen as active ingredients. European patent 1945234 (2012)

  • HK Kwon et al. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc Natl Acad Sci. 107(5):2159-64. (2010)

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