Principal Investigator

Prof. Sin-Hyeog Im
Professor, Department of Life Sciences, POSTECH
iimsh@postech.ac.kr

Education

  • 1983-1987 : B.Sc. Faculty of Life Sciences, Korea University, Seoul, Republic of Korea

  • 1987-1989 : M.Sc. Graduate School of Korea University, Seoul, Republic of Korea 

  • 1996-2001 : Ph.D. Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

Professional Record

  • 1990-1996 : Senior research scientist, Biotechnology Lab, Research center in Chong KunDang (CKD) Pharm, Seoul, Republic of Korea

  • 2001-2003 : Postdoctoral fellow, Harvard Medical School, USA (Prof. Anjana Rao's Lab)                                                                           
                        Subject : Functional Genomic Approaches for regulation of Immunoregulatory Molecules

  • 2004-2008 : Assistant Professor, Dept of Life Science, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea

  • 2008-2012 : Associates Professor, School of Life Science, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea

  • 2012-2013 : Professor, School of Life Science, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea

  • 2014-2019 : Group leader, Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS), Pohang, Republic of Korea

  • 2014-Present : Professor, Department of Life Sciences & Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology (POSTECH) Pohang, Republic of Korea

Selected Publications

  • C Lee et al. Structural specificities of cell surface beta-glucan polysaccharides determine commensal yeast-mediated immuno-modulatory activities. Nat Comm. (2021)

  • K Cho et al. Listeria monocytogenes establishes commensalism in Germ-Free mice through the reversible downregulation of virulence gene expression. Front Immunol. (2021)

  • HJ Kang, GC Kim & CG Lee et al. Probiotics--derived metabolite ameliorates skin allergy by promoting differentiation of Foxp3+ regulatory T cells. J Allergy Clin Immunol. (2021)

  • C Yang et al. Commensal microbiome expands Tgd17 cells in the lung and promotes particulate matter-induced acute neutrophilia. Front Immunol. (2021)

  • HJ Ko et al. Dietary glucose consumption promotes RALDH activity in small intestinal CD103+ CD11b+ dendritic cells. Front Immunol. (2020)

  • J Kim et al. Spontaneous Proliferation of CD4+ cells in Rag-deficient hosts  promottes antigen-independent but IL-2-dependent responses of naive strong CD8+ proliferative cells. Front Immunol. (2020)

  • JY Lee et al. TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity. OncoImmunol. (2020)

  • JE Kim & A Sharma et al. ​Lactobacillus pentosus modulates immune response by inducing IL-10 producing Tr1 cells. Immune Netw. (2019)

  • SN Hasan et al. Bcl11b prevents catastrophic auoimmunity by controlling multiple aspects of a regulatory T cell gene expression program. Sci Advances. (2019)

  • CG Lee et al. 1 suppresses atopic dermatitis by suppressing pathogenic T cell responses. JCI Insight. (2019)

  • GC Kim et al. Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness. Oncogenesis. (2018)

  • CJ Kim et al. The Transcription Factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus. Immunity. (2018)

  • R Verma et al. Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells. Sci Immunol (2018)

  • HK Kwon & GC Kim et al. Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program. Sci Rep. 18;6:19453. (2016) 

  • JU Shim, SE Lee & W Hwang et al. Flagellin suppresses experimental asthma by generating regulatory dendritic cells and T cells. J Allergy Clin Immunol. 137(2):426-35. (2016)

  • JE Kim, TX Pan & VH Nugyen et al. Salmonella typhimurium suppresses tumor growth via the pro-inflammatory cytokine interleukin-1β. Theranostics. 5(12):1328-1342. (2015)

  • JH Ryu & CS Chae et al. Hypoxia-Inducible Factor-2a Is an Essential Catabolic Regulator of Inflammatory Rheumatoid Arthritis. Plos  Biol. 12(6)21001881. (2014)

  • JS So, GC Kim & M Song et al. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. J Immunol.  193(6):2772-83. (2014)

  • A Jash et al. Nuclear factor of activated T cells 1 (NFAT1)-induced permissive chromatin modification facilitates Nuclear factor-kB (NFkB)-mediated interleukin-9 (IL-9) transactivation. J Biol Chem. 287(19):15445-57. (2012)

  • CG Lee et al. Interaction of Ets-1 with HDAC1 represses IL-10 expression in T helper 1 cells. J Immunol. 188(5):2244-253. (2012)

  • JS So, HJ Lee & SH Im. Composition for preventing or treating arthritis comprising lactic acid bacteria and collagen as active ingredients. European patent 1945234 (2012)

  • HK Kwon et al. Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc Natl Acad Sci. 107(5):2159-64. (2010)