Changes in gene transcription play a central role in regulating virtually all events from the development to the function of immune cells. We are interested in studying the role of immune related transcription factors (TFs), such as Ets, NFAT and ID family members. By using transgenic and conditional knockout mice, we aim to identify the functions of the TFs under homeostatic and disease conditions. At a mechanistic level, we are also applying various genomic and proteomic approaches to elucidate the corresponding molecular mechanisms.